Systemic exposure to a common periodontal pathogen and missing teeth are associated with metabolic syndrome.
Identifieur interne : 000052 ( Main/Exploration ); précédent : 000051; suivant : 000053Systemic exposure to a common periodontal pathogen and missing teeth are associated with metabolic syndrome.
Auteurs : K. Hyv Rinen [Finlande] ; A. Salminen ; V. Salomaa ; P J PussinenSource :
- Acta diabetologica [ 1432-5233 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Aggregatibacter actinomycetemcomitans (immunologie), Aggregatibacter actinomycetemcomitans (isolement et purification), Anticorps antibactériens (immunologie), Anticorps antibactériens (sang), Dent (), Dent (microbiologie), Femelle, Finlande (épidémiologie), Humains, Mâle, Parodontite (), Parodontite (immunologie), Parodontite (microbiologie), Perte dentaire (microbiologie), Porphyromonas gingivalis (immunologie), Porphyromonas gingivalis (isolement et purification), Sujet âgé, Études de cohortes.
- MESH :
- immunologie : Aggregatibacter actinomycetemcomitans, Anticorps antibactériens, Parodontite, Porphyromonas gingivalis.
- isolement et purification : Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis.
- microbiologie : Dent, Parodontite, Perte dentaire.
- sang : Anticorps antibactériens.
- épidémiologie : Finlande.
- Adulte d'âge moyen, Dent, Femelle, Humains, Mâle, Parodontite, Sujet âgé, Études de cohortes.
English descriptors
- KwdEn :
- Aged, Aggregatibacter actinomycetemcomitans (immunology), Aggregatibacter actinomycetemcomitans (isolation & purification), Antibodies, Bacterial (blood), Antibodies, Bacterial (immunology), Cohort Studies, Female, Finland (epidemiology), Humans, Male, Metabolic Syndrome (epidemiology), Metabolic Syndrome (etiology), Metabolic Syndrome (immunology), Middle Aged, Periodontitis (complications), Periodontitis (immunology), Periodontitis (microbiology), Porphyromonas gingivalis (immunology), Porphyromonas gingivalis (isolation & purification), Tooth (chemistry), Tooth (microbiology), Tooth Loss (microbiology).
- MESH :
- chemical , blood : Antibodies, Bacterial.
- chemistry : Tooth.
- complications : Periodontitis.
- epidemiology : Finland, Metabolic Syndrome.
- etiology : Metabolic Syndrome.
- immunology : Aggregatibacter actinomycetemcomitans, Antibodies, Bacterial, Metabolic Syndrome, Periodontitis, Porphyromonas gingivalis.
- isolation & purification : Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis.
- microbiology : Periodontitis, Tooth, Tooth Loss.
- Aged, Cohort Studies, Female, Humans, Male, Middle Aged.
Abstract
Periodontitis is a common chronic infection of tooth-supporting tissues leading to tooth loss. Two of the major periodontal pathogens are Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis. Clinically diagnosed periodontitis has been associated with metabolic syndrome (MetS). The aim of the study was to investigate the association of serum antibody levels against A. actinomycetemcomitans and P. gingivalis and the number of missing teeth with MetS. The population was the PAIS subcohort of the FINRISK '97 study (n = 1,354). The subjects were men aged 45-74 years, and they participated in this cardiovascular risk factor survey in Finland. A total of 534 (39 %) subjects had MetS defined according to the guidelines of the International Diabetes Federation. Serum antibody levels against the pathogens were measured by multiserotype ELISA. A. actinomycetemcomitans antibody levels and the number of missing teeth were significantly higher in subjects with a large waist circumference or with low serum high-density lipoprotein cholesterol. The number of missing teeth was also higher among subjects with a high serum triglyceride concentration or high plasma glucose concentration. Seropositivity for A. actinomycetemcomitans was significantly associated with MetS with an odds ratio (OR) 1.42 (95 % confidence interval 1.09-1.85, p = 0.009). More than four missing teeth and complete edentulousness were also significantly associated with MetS with ORs 1.69 (1.26-2.27, p < 0.001) and 1.93 (1.30-2.86, p = 0.001), respectively. Missing teeth and systemic exposure to A. actinomycetemcomitans were associated with several components of Mets. Infection with this common pathogen or the host response against it is associated with the presence of MetS.
DOI: 10.1007/s00592-014-0586-y
PubMed: 24791962
Affiliations:
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Le document en format XML
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Two of the major periodontal pathogens are Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis. Clinically diagnosed periodontitis has been associated with metabolic syndrome (MetS). The aim of the study was to investigate the association of serum antibody levels against A. actinomycetemcomitans and P. gingivalis and the number of missing teeth with MetS. The population was the PAIS subcohort of the FINRISK '97 study (n = 1,354). The subjects were men aged 45-74 years, and they participated in this cardiovascular risk factor survey in Finland. A total of 534 (39 %) subjects had MetS defined according to the guidelines of the International Diabetes Federation. Serum antibody levels against the pathogens were measured by multiserotype ELISA. A. actinomycetemcomitans antibody levels and the number of missing teeth were significantly higher in subjects with a large waist circumference or with low serum high-density lipoprotein cholesterol. The number of missing teeth was also higher among subjects with a high serum triglyceride concentration or high plasma glucose concentration. Seropositivity for A. actinomycetemcomitans was significantly associated with MetS with an odds ratio (OR) 1.42 (95 % confidence interval 1.09-1.85, p = 0.009). More than four missing teeth and complete edentulousness were also significantly associated with MetS with ORs 1.69 (1.26-2.27, p < 0.001) and 1.93 (1.30-2.86, p = 0.001), respectively. Missing teeth and systemic exposure to A. actinomycetemcomitans were associated with several components of Mets. Infection with this common pathogen or the host response against it is associated with the presence of MetS.</div></front></TEI><affiliations><list><country><li>Finlande</li></country><region><li>Uusimaa</li></region><settlement><li>Helsinki</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><noCountry><name sortKey="Pussinen, P J" sort="Pussinen, P J" uniqKey="Pussinen P" first="P J" last="Pussinen">P J Pussinen</name><name sortKey="Salminen, A" sort="Salminen, A" uniqKey="Salminen A" first="A" last="Salminen">A. Salminen</name><name sortKey="Salomaa, V" sort="Salomaa, V" uniqKey="Salomaa V" first="V" last="Salomaa">V. Salomaa</name></noCountry><country name="Finlande"><region name="Uusimaa"><name sortKey="Hyv Rinen, K" sort="Hyv Rinen, K" uniqKey="Hyv Rinen K" first="K" last="Hyv Rinen">K. Hyv Rinen</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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